Lymphocytic Hypophysitis in a Pregnant Woman: A Case Report
DOI:
https://doi.org/10.55677/IJCSMR/V4I1-01/2024Keywords:
Lymphocytic - Hypophysitis - Pregnancy - Management.Abstract
Introduction: Lymphocytic hypophysitis was first reported in 1962, it is a rare immune-mediated inflammatory disorder that causes pituitary dysfunction.
Case report: We report the case of 29-year-old woman at 37 weeks gestation, diagnosed with lymphocytic hypophysitis. The patient received appropriate hormonal replacement treatments. The evolution was favorable.
Conclusions: Lymphocytic hypophysitis is a rare auto-immune disease, occurring mainly in women during the peripartum phase. Clinical presentation is variable, it should be considered in female pregnant patients or in the early postpartum period, with pituitary hypertrophy and/or hormonal deficiencies with diabetes insipidus. To date, the management of this disease is challenging. Prospective controlled studies are necessary but difficult to conduct due to the rarity of lymphocytic hypophysitis.
References
Yu S, Bethanabatla R, Taha A. A case report of lymphocytic hypophysitis. Surg Neurol Int. 2021;12:263. Published 2021 Jun 7. doi:10.25259/SNI_225_2021
Ozawa A, Hiraga H, Okamura T, et al. A Case of Relapse of Lymphocytic Hypophysitis Triggered by the Pregnancy of the Second Child. J Endocr Soc. 2021;5(Suppl 1):A562-A563. Published 2021 May 3. doi:10.1210/jendso/bvab048.1146
Diego, E. , Ciudin, A. , Simo-Servat, O. , Ortiz, A. , Gutierrez-Carrasquilla, L. and Mesa, J. (2015) A Case Report of Lymphocytic Hypophysitis Related to Pregnancy. Open Journal of Endocrine and Metabolic Diseases, 5, 171-176.
doi: 10.4236/ojemd.2015.512021.
Faje, A. Hypophysitis: Evaluation and Management. Clin Diabetes Endocrinol 2, 15 (2016). https://doi.org/10.1186/s40842-016-0034-8
Rawanduzy CA, Winkler-Schwartz A, Couldwell WT. Hypophysitis: Defining Histopathologic Variants and a Review of Emerging Clinical Causative Entities. International Journal of Molecular Sciences. 2023; 24(6):5917.
https://doi.org/10.3390/ijms24065917
Biswas M; H. Thackare; M.K. Jones; P. Bowen-Simpkins (2002). Lymphocytic hypophysitis and headache in pregnancy. ,109(10),1184–1186. doi:10.1111/j.1471-0528.2002.01158.x
Kuntal, Smriti; Manjambigai, Sivaprakasam (2016). Lymphocytic hypophysitis in pregnancy leading to diabetes insipidus a rare disease and a diagnostic challenge. European Journal of Obstetrics & Gynecology and Reproductive Biology, 206(), e66 doi:10.1016/j.ejogrb.2016.07.185
Gutenberg, A., Hans, V., Puchner, M.J., Kreutzer, J., Brück, W., Caturegli, P. and Buchfelder, M. (2006) Primary Hypophysitis: Clinical-Pathological Correlations. European Journal of Endocrinology, 155, 101-107. http://dx.doi.org/10.1530/eje.1.02183
Davies, Emma C.; Jakobiec, Frederick A.; Stagner, Anna M.; Rizzo, Joseph F. (2016). An Atypical Case of Lymphocytic Panhypophysitis in a Pregnant Woman. Journal of Neuro-Ophthalmology, (), 1–. doi:10.1097/wno.0000000000000362
Molitch, Mark E.; Gillam, Mary P. (2007). Lymphocytic Hypophysitis. Hormone Research, 68(5), 145–150. doi:10.1159/000110611
Kyriacou, Angelos; Gnanalingham, Kanna; Kearney, Tara (2017). Lymphocytic hypophysitis: modern day management with limited role for surgery. Pituitary, 20(2), 241–250. doi:10.1007/s11102-016-0769-3
Joshi, Mamta N; Whitelaw, Benjamin; Carroll, Paul V (2018). MANAGEMENT OF ENDOCRINE DISEASE: Hypophysitis - diagnosis and treatment. European Journal of Endocrinology, (), EJE-17-0009–. doi:10.1530/EJE-17-0009
Lin M, Tsang V, Brewer J, Clifton-Bligh R, Gild ML. Infiltrative lymphocytic hypophysitis successfully treated with rituximab and mycophenolate mofetil. Endocrinol Diabetes Metab Case Rep. Published online July 29, 2020. doi:10.1530/EDM-20-0041
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 International Journal of Clinical Science and Medical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
