Cardiovascular Sequelae of COVID-19 in Adult Population: A Scoping Review

Authors

  • Mario Iván Kirsch-Cepeda Department of Internal Medicine, “Dr. Carlos Mac Gregor Sánchez Navarro” Regional General Hospital Number 1, Mexican Social Security Institute. 222 Gabriel Mancera street, Mexico City, Mexico
  • Joel Alejandro Méndez-Jiménez Department of Internal Medicine, “Dr. Carlos Mac Gregor Sánchez Navarro” Regional General Hospital Number 1, Mexican Social Security Institute. 222 Gabriel Mancera street, Mexico City, Mexico
  • Luis Guillermo Moreno-Madrigal Department of Internal Medicine, “Dr. Carlos Mac Gregor Sánchez Navarro” Regional General Hospital Number 1, Mexican Social Security Institute. 222 Gabriel Mancera street, Mexico City, Mexico

DOI:

https://doi.org/10.55677/IJCSMR/V4I5-06/2024

Keywords:

COVID-19, SARS-CoV-2, Complications, Post-Acute COVID-19 Syndrome, Cardiovascular Diseases

Abstract

The COVID-19 pandemic had an unprecedented impact on healthcare systems and the global population. Investigating cardiac complications following COVID-19 recovery holds vital clinical importance, given its scope in the development of post-discharge monitoring programs for patients, as well as the economic and healthcare implication involved. The scoping review aimed to provide a summary of the current and available evidence related to cardiovascular sequelae in adult patients who had COVID-19. Research evidence, published in the last three years (2021 to October 2023), was retrieved in English and Spanish. A total of 746 articles were identified and only 12 that met the inclusion criteria were selected for this review. The most common persistent symptoms reported were dyspnea and fatigue, followed by palpitations and chest pain. Cardiac complications of SARS-CoV-2 virus infection include myocarditis, vasculitis, acute coronary syndrome, right ventricular dysfunction, pericarditis and myocardial infarction. Although the COVID-19 health emergency has ended on an international scale, the consequences of SARS-CoV-2 infection, particularly the cardiovascular sequelae, remain a public health concern due to the associated morbidity and mortality. Documentation and knowledge of the main characteristics of cardiovascular sequelae is crucial for their extent in the development of post-discharge monitoring programs for patients with COVID-19, as well as for health and economic implications.

References

Khetpal V, Berkowitz J, Vijayakumar S, Choudary G, Mukand JA, Rudolph JL, et al. Long-term Cardiovascular Manifestations and Complications of COVID-19: Spectrum and Approach to Diagnosis and Management. R I Med J (2013). 2022;105(7):16-22. http://www.ncbi.nlm.nih.gov/pubmed/35930485

Raman B, Bluemke DA, Lüscher TF, Neubauer S. Long COVID: Post-Acute sequelae of COVID-19 with a cardiovascular focus. Eur Heart J. 2022;43(11):1157- 1172.

doi:10.1093/eurheartj/ehac031

Desai AD, Lavelle M, Boursiquot BC, Wan EY. Long-term complications of COVID-19. Am J Physiol - Cell Physiol. 2022;322(1):C1-C11. doi:10.1152/AJPCELL.00375.2021

Tricco AC, Lillie E, Zarin W, O´Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. Ann Intern Med. 2018;169(7):467-473. doi:10.7326/M18-0850

Xie Y, Xu E, Bowe B, Al-Aly Z. Long-term cardiovascular outcomes of COVID-19.Nat Med. 2022;28(3):583-590. doi:10.1038/s41591-022-01689-3

Wang W, Wang CY, Wang SI, Wei JCC. Long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population: A retrospective cohort study from the TriNetX US collaborative networks. eClinicalMedicine. 2022;53(110):101619. doi:10.1016/j.eclinm.2022.101619

Kunal S, Bagarhatta P, Palleda GM, Bansal A, Batra V, Daga MK, et al. Role of cardiovascular magnetic resonance imaging in COVID-19 recovered patients: A short-term follow-up study. Echocardiography. 2022;39(11):1401-1411. doi:10.1111/echo.15466

Ortega-Paz L, Arévalos V, Fernández-Rodríguez D, Jiménez-Díaz V, Bañeras J, Campo G, et al. One-year cardiovascular outcomes after coronavirus disease 2019: The cardiovascular COVID-19 registry. PLoS One. 2022;17(12 December):1-18.

doi:10.1371/journal.pone.0279333

González-Hermosillo J, Galarza J, Fermín OV, González JMN, Tostado LMFÁ, Lozano MAE, et al. Exaggerated blood pressure elevation in response to orthostatic challenge, a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization. Auton Neurosci Basic Clin. 2023;247. doi:https://doi.org/10.1016/j.autneu.2023.103094

Hamdy RM, Abdelaziz OH, Shamsseldain HE, Eltrawy HH. Functional outcomes in post Covid-19 patients with persistent dyspnea: multidisciplinary approach. Int J Cardiovasc Imaging. 2023;39(6):1115-1122. doi:10.1007/s10554-023-02819-9

Mancini D, Brunjes D, Lala A, Trivieri M, Contreras J, Natelson B. Use of Cardiopulmonary Stress Testing for Patients With Unexplained Dyspnea Post– Coronavirus Disease. JACC Hear Fail. 2021;9(12):927-937. doi:https://doi.org/10.1016/j.jchf.2021.10.002

Aranyó J, Bazan V, Lladós G, Dominguez MJ, Bisbal F, Massanella M, et al. Inappropriate sinus tachycardia in post-COVID- 19 syndrome. Sci Rep. 2022;12(1):1-9. doi:10.1038/s41598-021-03831-6

Gorecka M, Jex N, Thirunavukarasu S, Chowdhary A, Corrado J, Davison J, et al. Cardiovascular magnetic resonance imaging and spectroscopy in clinical long-COVID-19 syndrome: a prospective case– control study. J Cardiovasc Magn Reson. 2022;24(1):1-11. doi:10.1186/s12968-022- 00887-9

Clark DE, Dendy JM, Li DL, Crum K, Dixon D, George-Durrett K, et al. Cardiovascular magnetic resonance evaluation of soldiers after recovery from symptomatic SARS-CoV-2 infection: a case–control study of cardiovascular post-acute sequelae of SARS-CoV-2 infection (CV PASC). J Cardiovasc Magn Reson. 2021;23(1):1-9. doi:10.1186/s12968-021-00798-1

Wiemken TL, McGrath LJ, Andersen KM, Khan F, Malhotra D, Alfred T, et al. Coronavirus Disease 2019 Severity and Risk of Subsequent Cardiovascular Events. Clin Infect Dis. 2023;76(3):E42- E50. doi:10.1093/cid/ciac661

Mahmoud Z, East L, Gleva M, Woodard PK, Lavine K, Verma AK. Cardiovascular symptom phenotypes of post-acute sequelae of SARS-CoV-2. Int J Cardiol. 2022;366:35-41. doi:https://doi.org/10.1016/j.ijcard.2022.07.018

Huseynov A, Akin I, Duerschmied D, Scharf RE. Cardiac Arrhythmias in Post- COVID Syndrome: Prevalence, Pathology, Diagnosis, and Treatment. Viruses. 2023;15(2):1-15. doi:10.3390/v15020389

Zuin M, Rigatelli G, Roncon L, Pasquetto G, Bilato C. Risk of incident heart failure after COVID-19 recovery: a systematic review and meta-analysis. Heart Fail Rev. 2023;28(4):859-864. doi:10.1007/s10741-022-10292-0

Petersen SE, Friedrich MG, Leiner T, Elias MD, Ferreira VM, Fenski M, et al. Cardiovascular Magnetic Resonance for Patients With COVID-19. JACC Cardiovasc Imaging. 2022;15(4):685-699. doi:10.1016/j.jcmg.2021.08.021

Ruberg FL, Baggish AL, Hays AG, Jerosch-Herold M, Kim J, Ordovas KG, et al. Utilization of cardiovascular magnetic resonance (CMR) imaging for resumption of athletic activities following COVID-19 infection: an expert consensus document on behalf of the American Heart Association Council on Cardiovascular Radiology and Interventio. J Cardiovasc Magn Reson. 2022;24(1):1-15. doi:10.1186/s12968-022-00907-8

Yan MZ, Yang M, Lai CL. Post-COVID-19 Syndrome Comprehensive Assessment: From Clinical Diagnosis to Imaging and Biochemical-Guided Diagnosis and Management. Viruses. 2023;15(2). doi:10.3390/v15020533

Tabacof L, Tosto-Mancuso J, Wood J, Cortes M, Kontorovich A, McCarthy D, et al. Post-acute COVID-19 Syndrome Negatively Impacts Physical Function, Cognitive Function, Health-Related Quality of Life, and Participation. Am J Phys Med Rehabil. 2022;101(1):48-52.

doi:10.1097/PHM.0000000000001910

Ashton RE, Philips BE, Faghy M. The acute and chronic implications of the COVID-19 virus on the cardiovascular system in adults: A systematic review. Prog Cardiovasc Dis. 2023;76:31-37. doi:https://doi.org/10.1016/j.pcad.2023.01.003

Tobler DL, Pruzansky AJ, Naderi S, Ambrosy AP, Slade JJ. Long-Term Cardiovascular Effects of COVID-19: Emerging Data Relevant to the Cardiovascular Clinician. Curr Atheroscler Rep. 2022;24(7):563-570. doi:10.1007/s11883-022-01032-8

Alvarez-Moreno CA, Pineda J, Bareño A, Espitia R, Rengifo P. Long COVID-19 in Latin America: Low prevalence, high resilience or low surveillance and difficulties accessing health care? Travel Med Infect Dis. 2023;51.

doi:https://doi.org/10.1016/j.tmaid.2022.102492

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Published

2024-05-30

How to Cite

Kirsch-Cepeda, M. I., Méndez-Jiménez, J. A., & Moreno-Madrigal, L. G. (2024). Cardiovascular Sequelae of COVID-19 in Adult Population: A Scoping Review. International Journal of Clinical Science and Medical Research, 4(5), 170–179. https://doi.org/10.55677/IJCSMR/V4I5-06/2024