Evaluating the Effectiveness of Ohtuvayre Regimen Over Albuterol in COPD Management

Abstract

One of the main causes of morbidity and poor health worldwide is Chronic Obstructive Pulmonary Disease (COPD) (World Health Organisation, 2024.). Over the last two decades, inhalation treatments had not advanced very much. Still, the U.S. Food and Drug Administration (FDA)'s recent approval of Ohtuvayre (ensifentrine) has brought a first-inclass inhalation medication combining bronchodilator and anti-inflammatory properties via dual inhibition of phosphodiesterase enzymes PDE3 and PDE4. Many trials have confirmed the usage of the new medicine by showing considerable increases in forced expiratory volume in one second (FEV1), therefore improving lung function. The Fatima et al. (2025) study indicates that patients reported to have greater quality of life (QoL), which was evaluated using the St. George's Respiratory Questionnaire-C, and less dyspnea, measured by the Transition Dyspnea Index. While this drug is also proven not to cause notable rise in adverse events compared to placebo, other studies also revealed that it offers a good safety profile. These results, indeed, indicate Ohtuvayre as a possible transforming COPD treatment. These days, providers have a better solution for controlling symptoms and improving patient outcomes. Patients who have been poorly controlled by current bronchodilators and inhaled corticosteroids would especially benefit from this medicine. That said, this study investigates elements including the mechanism of action, clinical efficacy, safety profile, and relative benefits of Ohtuvayre over current COPD medications.