International Journal of Clinical Science and Medical Research

Background: Neck circumference and vitamin D have been linked with risk of development of chronic disorders especially those with cardiovascular implications, including type 2 diabetes mellitus. This study aimed to examine the relationship between neck circumference and vitamin D among persons with type 2 diabetes.

Method: The design of the research work was comparative cross-sectional, which included a total of 180 persons, comprising 120 patients with type 2 diabetes and 60 healthy controls. Neck circumference of subjects with type 2 diabetesand controls was measured, alongside determination of vitaminD levels for both categories of individuals. Data obtained was analyzed with Statistical Package for Social Sciences, version 22.

Results: The mean neck circumference of subjects with type 2 diabetes compared with controls showed no statistical difference (34.30 ± 3.09 cm vs 34.81 ± 2.61 cm; p>0.05). Neck circumference of male subjects with type 2 diabeteswas higher than their female counterparts and thiswas statistically significant (37.46±2.97 cm vs 33.05±2.09 cm; p=0.01). The mean serum vitamin D of the subjects with type 2 diabetes was significantly lower than the controls (35.84 ± 11.65ng/ml vs 44.71 ± 20.12ng/ml; p< 0.001). However, there was no correlation between neck circumference and vitamin D amongst individuals with diabetes (rho= -0.07; p=0.46). 

Conclusion: Neck circumference was not associated with vitamin D among subjects with type 2 diabetes in this study population. Furtherlocal and intercontinental studies may be required to fully elucidateon the existence of relationship between neck circumference and vitamin D amongst individuals with diabetes mellitus.

Neck circumference, Vitamin D, Type 2 diabetes mellitus, chronic diseases

1. Bouillon R, Carmeliet G, Verlinden L, van Etten E, VerstuyfA, Luderer HF, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocrine Reviews. 2008;29(6):726-76.
2. Shobach D, Schafer A, Bikle D. Metabolic Bone Disease. In: Gardner D, Shobach D, (eds). Greenspan's Basic & Clinical Endocrinology. 10th ed. China. McGraw-Hill; 2018. p. 239-253.
3. Parker J, Hashmi O, Dutton D, Mavrodaris A, Stranges S, Kandala N-B, et al. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas. 2010;65(3):225-36.
4. WangC. Role of vitamin D in cardiometabolic diseases. J DiabetesRes. 2013;2013:243934.
5. Adeleye JO, Emuze ME, Esan A, Bamidele OT. Serum vitaminD status and its relationship with insulin resistance amongst a cohort of Nigerian patients with type 2 diabetes mellitus. Journal of Diabetology. 2023 Oct 1;14(4):220-5.
6. Jorde R, Sneve M, Emaus N, Figenschau Y, Grimnes G. Cross-sectional and longitudinal relation between serum 25-hydroxyvitamin D and body mass index: the Tromso study. European Journal of Nutrition. 2010;49(7):401-7.
7. Oputa R, Chinenye S. Diabetes in Nigeria–a translational medicine approach. AfricanJournal of Diabetes Medicine. 2015;23(1).
8. Defronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58(4):773-95.
9. Gowda, KS, Reshma S, Asharani N, Dsa, J. Neck Circumference as an Indicator of Glycemic Status in Type 2 Diabetes Mellitus: Evidence from a Tertiary Care Hospital of Mangaluru. YMER Digital. 2024 Nov; 23. 1367. doi: 10.37896/YMER23.10/A0
10. Dada, Akinola Olusola; Mumani, Amisu A.; Okunowo, Bolanle Olajumoke. Neck circumference and cardiometabolic syndrome in adult patients at a tertiary hospital in Lagos, Nigeria: A cross-sectional study. Journal of Clinical Sciences 20(3):p 98-103, Jul–Sep 2023. | DOI: 10.4103/jcls.jcls_10_23
11. FuJ, Han L, Zhao Y, Li G, Zhu Y, Li Y, et al. Vitamin D levels are associated with metabolic syndrome in adolescents and young adults: The BCAMS study. Clinical nutrition. 2019 Oct 1;38(5):2161-7.
12. ChenYA, Chang WJ, Liao TW, Hung WS, Tung PH, Lin SW, et al. A Prospective Observational Study Investigating the Relationship Between Vitamin D Deficiency and STOP-Bang Parameters in Elderly Populations. Nature and Science of Sleep. 2025 Dec 31:2399-410.
13. International Diabetes Federation. IDF Diabetes Atlas,11th edn. Brussels,Belgium: International Diabetes Federation, 2025. http://www.diabetesatlas.org. Accessed October 7, 2025.
14. Kish L. A procedure for objective respondent selection within the household. Journal of the American Statistical Association. 1949;44(247):380-7.
15. Fondjo LA, Owiredu WK, Sakyi SA, Laing EF, Adotey-Kwofie MA, Antoh EO, et al. Vitamin D status and its association with insulin resistance among type 2 diabetics: A case-control study in Ghana. PloS one. 2017;12(4):e0175388.
16. Kumar NV, Ismail MH, Tripathy M. Neck circumference and cardio-metabolic syndrome. Journal of Clinical and Diagnostic Research: JCDR. 2014 Jul 20;8(7):MC23.
17. Ben-Noun LL, Laor A. Relationship between changes in neck circumference and cardiovascular risk factors. Experimental & Clinical Cardiology. 2006;11(1):14.
18. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism. 2011;96(7):1911-30.
19. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences–. The American Journal of Clinical Nutrition. 2008;87(4):1080S-6S.
20. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner R. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. diabetologia. 1985 Jul;28(7):412-9.
21. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes care. 2004 Jun 1;27(6):1487-95.
22. LiD, Zhao Y, Zhang L, You Q, Jiang Q, Yin X, Cao S. Association betweenneck circumference and diabetes mellitus: a systematic review and meta-analysis. Diabetology & Metabolic Syndrome. 2023 Jun 21;15(1):133.
23. Abbiyesuku F, Olawale O, Agbakwuru A, Olooto W. Vitamin D Levels and Insulin Resistance among Nigerian Men with Type-2 Diabetes mellitus. Annals of Health Research. 2016;2(1):10-6
24. Fondjo LA, Owiredu WK, Sakyi SA, Laing EF, Adotey-Kwofie MA, Antoh EO, et al. Vitamin D status and its association with insulin resistance among type 2 diabetics: A case-control study in Ghana. PloS one. 2017;12(4):e0175388.
25. Kostoglou-Athanassiou I, Athanassiou P, Gkountouvas A, Kaldrymides P. Vitamin D and glycemic control in diabetes mellitus type 2. Ther Adv Endocrinol Metab. 2013;4(4):122-8.
26. Bachali S, Dasu K, Ramalingam K, Naidu JN. Vitamin d deficiency and insulin resistance in normal and type 2 diabetes subjects. Indian J Clin Biochem. 2013;28(1):74-8.
27. Cho NH, Oh TJ, Kim KM, Choi SH, Lee JH, Park KS, et al. Neck circumference and incidence of diabetes mellitusover 10 years in the Korean Genome and Epidemiology Study (KoGES). Scientific reports. 2015 Dec 18;5(1):18565.
28. Lucas RE, Fonseca AL, Dantas RO. Neck circumference can differentiate obese from nonobese individuals. MedicalExpress. 2016;3(4):M160403.
29. ZhaoG, Ford ES, Li C. Associations of Serum Concentrations of 25-Hydroxyvitamin D and Parathyroid Hormone with Surrogate Markersof Insulin Resistance among US Adultswithout Physician-Diagnosed Diabetes: National Health and Nutrition Examination Survey, 2003-2006. Diabetes Care. 2010;33(2):344-7.